Hypercold Air Mechanical
Ventilation Targeted Temperature
Management System

Problem Statement

over 35 million people worldwide die from sudden death severe stroke, brain injury or Acute Lung Injury
Many of them can be saved with total body cooling to about 32-34 Co if it is achieved during the first 1-2 hours following catastrophic event.
Targeted Temperature Management (formally known as Therapeutic Hypothermia) was introduced to medical practice in early 2000s.
Current Therapeutic Hypothermia Methods are ineffective either due to the slow rate of cooling, or impractical design, high complexity or high rate of serious side effects.
Our new Therapeutic Hypothermia System will bring dramatic changes.

Cooling body wraps are simple and easy to use, but they don’t provide fast rate of cooling, and limit access to a patient for diagnostic or life saving procedures.
Imitation of ice water immersion provides fast rate of cooling, has no serious complications, but the equipment is very heavy and blocks access to a patient for diagnostic or life saving procedures.
Venous devices percolated with ice water require specialized training, don’t provide fast rate of cooling, and have serious side effects.
Extracorporeal cooling provides fast rate of cooling, but it can only be done in a small number of larger hospitals, requires highly trained and specialized staff, and has high rate of complications.
Esophageal cooling device is easy to use, does not have serious complications, but does not provide fast rate of cooling.

Our method, called Hypercold Air Mechanical Ventilation uses lungs high surface area as a heat exchanger
Patients who stand to gain from (TTM) are already undergoing mechanical ventilation, with the only necessary adjustment being the incorporation of cooling air into the ventilation circuit for hypothermia induction.
New TTM System will be easy to use, portable, provide a fast rate of cooling to achieve target body temperature within 1 hours after the start and lack side effects.

Our cooling device consists of a small freezer filled with a cooling media which does not solidify at subfreezing temperature (for example, 28% CaCl solution).
The freezer has a copper coil immersed into cooling media.
The coil is attached to a mechanical ventilator tubing on one end and to a patient’s breathing tube on another end.
The temperature of the cooling media can be changed as needed to meet the clinical goals.
The air runs from the mechanical ventilator through the freezer to the patient at fast flow, while the patient is ventilated at higher rate than physiologically necessary.
The excessive removal of CO2 caused by high rate of ventilation is compensated by adding CO2 to inhaled air producing what we call Compensated Hyperventilation™️.

Reaches target temperature within 1 hour.
Minimally invasive: All patients undergoing therapeutic hypothermia receive mechanical ventilation due to the nature of their condition and have an endotracheal (breathing) tube already inserted.
Allows for unobstructed access to the patient for diagnostic and life saving procedures.
Compact and portable, facilitates use throughout patient transport and minimizes equipment crowding.
Allows for initiation of hypothermia in prehospital settings, such as ground or air ambulances.
Easy to operate by minimally trained staff; only requires placing device in line with the ventilator tubing.
Suitable for induction of hypothermia in patients with Acute Lung Injury by providing a direct pulmonary cooling effect.

Ambulances

Assumes one units per ambulances

Hospital

Assumes two units per hospital